Comparative analysis of bispecific antibody and streptavidin-targeted radioimmunotherapy for B cell cancers

Streptavidin (SA)-biotin pretargeted radioimmunotherapy (PRIT) that targets CD20 in non-Hodgkin lymphoma (NHL) exhibits remarkable efficacy in model systems, but SA immunogenicity and interference by endogenous biotin may complicate clinical translation of this approach. In this study, we engineered...

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Udgivet i:Cancer Res
Main Authors: Green, Damian J., Frayo, Shani L., Lin, Yukang, Hamlin, Donald K., Fisher, Darrell R., Frost, Sofia H.L., Kenoyer, Aimee L., Hylarides, Mark D., Gopal, Ajay K., Gooley, Theodore A., Orozco, Johnnie J., Till, Brian G., O’Steen, Shyril, Orcutt, Kelly D., Wilbur, D. Scott, Wittrup, K. Dane, Press, Oliver W.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290195/
https://ncbi.nlm.nih.gov/pubmed/27590740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0571
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