Infiltration of CD8 T cells and expression of PD-1 and PD-L1 in synovial sarcoma

Tumors expressing programmed death ligand 1 (PD-L1) interact with the corresponding negative-signal generating immune receptor on the surface of CD8 T cells, PD-1, thereby suppressing antitumor activity. Therapeutics blocking this interaction have shown promise in various cancers by restoring functi...

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Vydáno v:Cancer Immunol Res
Hlavní autoři: Nowicki, Theodore S., Akiyama, Ryan, Huang, Rong Rong, Shintaku, I. Peter, Wang, Xiaoyan, Tumeh, Paul C., Singh, Arun, Chmielowski, Bartosz, Denny, Christopher, Federman, Noah, Ribas, Antoni
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290092/
https://ncbi.nlm.nih.gov/pubmed/28039162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-16-0148
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