Ultraviolet B Inhibits IL-17A/TNF-α-Stimulated Activation of Human Dermal Fibroblasts by Decreasing the Expression of IL-17RA and IL-17RC on Fibroblasts

BACKGROUND: Psoriasis is a chronic immune-mediated inflammatory disease, and a mixed Th1/Th17 cytokine environment plays a critical role in the pathogenesis of psoriasis. Dermal fibroblasts secrete certain cytokines such as IL-6, IL-8, and CXCL-1, contributing to the hyperproliferative state of the...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Yin, Li, Hu, YingYing, Xu, JiaLi, Guo, Jing, Tu, Jie, Yin, ZhiQiang
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5289959/
https://ncbi.nlm.nih.gov/pubmed/28217129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00091
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