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Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia

We recently generated 2 phenotypically similar Hoxa9+Meis1 overexpressing acute myeloid leukemias that differ by their in vivo biologic behavior. The first leukemia, named FLA2, shows a high frequency of leukemia stem cells (LSCs; 1 in 1.4 cells), whereas the second, FLB1, is more typical with a fre...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Trost, Matthias, Sauvageau, Martin, Hérault, Olivier, Deleris, Paul, Pomiès, Christelle, Chagraoui, Jalila, Mayotte, Nadine, Meloche, Sylvain, Sauvageau, Guy, Thibault, Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5289887/
https://ncbi.nlm.nih.gov/pubmed/22802335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-12-397844
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