EpCAM-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis B virus-infected hepatocytes

BACKGROUND & AIMS: Hepatocytes in which the hepatitis B virus (HBV) is replicating exhibit loss of the chromatin modifying polycomb repressive complex 2 (PRC2), resulting in re-expression of specific, cellular PRC2-repressed genes. Epithelial cell adhesion molecule (EpCAM) is a PRC2-repressed ge...

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Vydáno v:J Hepatol
Hlavní autoři: Mani, Saravana Kumar Kailasam, Zhang, Hao, Diab, Ahmed, Pascuzzi, Pete E., Lefrançois, Lydie, Fares, Nadim, Bancel, Brigitte, Merle, Philippe, Andrisani, Ourania
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5289705/
https://ncbi.nlm.nih.gov/pubmed/27238755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2016.05.022
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