The biodistribution of 5-[(18)F]fluoropyrazinamide in Mycobacterium tuberculosis-infected mice determined by positron emission tomography

5-[(18)F]F-pyrazinamide (5-[(18)F]F-PZA), a radiotracer analog of the first-line tuberculosis drug pyrazinamide (PZA), was employed to determine the biodistribution of PZA using PET imaging and ex vivo analysis. 5-[(18)F]F-PZA was synthesized in 60 min using a halide exchange reaction. The overall d...

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Publicat a:PLoS One
Autors principals: Zhang, Zhuo, Ordonez, Alvaro A., Smith-Jones, Peter, Wang, Hui, Gogarty, Kayla R., Daryaee, Fereidoon, Bambarger, Lauren E., Chang, Yong S., Jain, Sanjay K., Tonge, Peter J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5289470/
https://ncbi.nlm.nih.gov/pubmed/28151985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170871
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