Design and structural characterization of potent and selective inhibitors of phosphatidylinositol 4 kinase IIIβ

Type III Phosphatidylinositol 4-kinase (PI4KIIIβ) is an essential enzyme in mediating membrane trafficking, and is implicated in a variety of pathogenic processes. It is a key host factor mediating replication of RNA viruses. The design of potent and specific inhibitors of this enzyme will be essent...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Rutaganira, Florentine U., Fowler, Melissa L., McPhail, Jacob A., Gelman, Michael A., Nguyen, Khanh, Xiong, Anming, Dornan, Gillian L., Tavshanjian, Brandon, Glenn, Jeffrey S., Shokat, Kevan M., Burke, John E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5289284/
https://ncbi.nlm.nih.gov/pubmed/26885694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01311
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