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Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging
Mammalian genes frequently present allelic variants that differ in their expression levels and that, in the case of tumor suppressor genes, can be of relevance for cancer susceptibility and aging. We report here the characterization of a novel mouse model with increased activity for the Ink4a and Ar...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2004
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC528894/ https://ncbi.nlm.nih.gov/pubmed/15520276 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.310304 |
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