LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis

Wnt signaling, which is mediated by LEF1/TCF transcription factors, has been placed upstream of the Notch pathway in vertebrate somitogenesis. Here, we examine the molecular basis for this presumed hierarchy and show that a targeted mutation of Lef1, which abrogates LEF1 function and impairs the act...

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Библиографические подробности

Опубликовано в::	Genes Dev
Главные авторы:	Galceran, Juan, Sustmann, Claudio, Hsu, Shu-Chi, Folberth, Stephanie, Grosschedl, Rudolf
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Cold Spring Harbor Laboratory Press 2004
Предметы:	Research Communications
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC528889/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15545629/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1249504
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