Simvastatin suppresses the DNA replication licensing factor MCM7 and inhibits the growth of tamoxifen-resistant breast cancer cells

Acquired tamoxifen resistance (TamR) remains a major challenge in breast cancer endocrine therapy. The mechanism of acquiring tamoxifen resistance remains elusive, and no effective drugs are available. In this investigation, we determined that the expression of the DNA damage marker γH2AX is upregul...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Liang, Zheyong, Li, Wenjie, Liu, Jie, Li, Juan, He, Fang, Jiang, Yina, Yang, Lu, Li, Pingping, Wang, Bo, Wang, Yaochun, Ren, Yu, Yang, Jin, Luo, Zhijun, Vaziri, Cyrus, Liu, Peijun
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288718/
https://ncbi.nlm.nih.gov/pubmed/28150753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41776
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