The mutational profile and infiltration pattern of murine MLH1(-/-) tumors: concurrences, disparities and cell line establishment for functional analysis

Mice lines homozygous negative for one of the four DNA mismatch repair (MMR) genes (MLH1, MSH2, PMS2, MSH6) were generated as models for MMR deficient (MMR-D) diseases. Clinically, hereditary forms of MMR-D include Lynch syndrome (characterized by a germline MMR gene defect) and constitutional MMR-D...

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Vydáno v:Oncotarget
Hlavní autoři: Maletzki, Claudia, Beyrich, Franziska, Hühns, Maja, Klar, Ernst, Linnebacher, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288207/
https://ncbi.nlm.nih.gov/pubmed/27447752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10677
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