The mutational profile and infiltration pattern of murine MLH1(-/-) tumors: concurrences, disparities and cell line establishment for functional analysis

Mice lines homozygous negative for one of the four DNA mismatch repair (MMR) genes (MLH1, MSH2, PMS2, MSH6) were generated as models for MMR deficient (MMR-D) diseases. Clinically, hereditary forms of MMR-D include Lynch syndrome (characterized by a germline MMR gene defect) and constitutional MMR-D...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Oncotarget
Päätekijät: Maletzki, Claudia, Beyrich, Franziska, Hühns, Maja, Klar, Ernst, Linnebacher, Michael
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Impact Journals LLC 2016
Aiheet:
Research Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288207/
https://ncbi.nlm.nih.gov/pubmed/27447752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10677
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