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The mutational profile and infiltration pattern of murine MLH1(-/-) tumors: concurrences, disparities and cell line establishment for functional analysis

Mice lines homozygous negative for one of the four DNA mismatch repair (MMR) genes (MLH1, MSH2, PMS2, MSH6) were generated as models for MMR deficient (MMR-D) diseases. Clinically, hereditary forms of MMR-D include Lynch syndrome (characterized by a germline MMR gene defect) and constitutional MMR-D...

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Библиографические подробности
Опубликовано в: :Oncotarget
Главные авторы: Maletzki, Claudia, Beyrich, Franziska, Hühns, Maja, Klar, Ernst, Linnebacher, Michael
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288207/
https://ncbi.nlm.nih.gov/pubmed/27447752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10677
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