Ex-vivo Clonally Expanded B Lymphocytes Infiltrating Colorectal Carcinoma Are of Mature Immunophenotype and Produce Functional IgG

BACKGROUND: Tumor infiltrating B cells (TiBc) have not yet been investigated in detail. This may at least in part be due to technical difficulties. Here we describe a straightforward and reproducible method to isolate and culture TiBc from primary colorectal carcinomas (CRC). METHODS/RESULTS: TiBc c...

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Detalhes bibliográficos
Main Authors: Maletzki, Claudia, Jahnke, Annika, Ostwald, Christiane, Klar, Ernst, Prall, Friedrich, Linnebacher, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290587/
https://ncbi.nlm.nih.gov/pubmed/22393427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032639
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