The underlying mechanism of proinflammatory NF-κB activation by the mTORC2/Akt/IKKα pathway during skin aging

Mammalian target of rapamycin complex 2 (mTORC2), one of two different enzymatic complexes of mTOR, regulates a diverse set of substrates including Akt. mTOR pathway is one of well-known mediators of aging process, however, its role in skin aging has not been determined. Skin aging can be induced by...

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Pubblicato in:Oncotarget
Autori principali: Choi, Yeon Ja, Moon, Kyoung Mi, Chung, Ki Wung, Jeong, Ji Won, Park, Daeui, Kim, Dae Hyun, Yu, Byung Pal, Chung, Hae Young
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper: Gerotarget (Focus on Aging)
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288141/
https://ncbi.nlm.nih.gov/pubmed/27486771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10943
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