Activation of proinflammatory signaling by 4-hydroxynonenal-Src adducts in aged kidneys

In our previous study, reactive 4-hydroxy-2-nonenal (4-HNE) was shown to activate Src (a non-receptor tyrosine kinase) by forming an adduct on binding with a specific residue of Src, leading to the activation of proinflammatory signaling pathways in cultured cells. However, to date, the deleterious...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Jang, Eun Ji, Kim, Dae Hyun, Lee, Bonggi, Lee, Eun Kyeong, Chung, Ki Wung, Moon, Kyoung Mi, Kim, Min Jo, An, Hye Jin, Jeong, Ji Won, Kim, Ye Ra, Yu, Byung Pal, Chung, Hae Young
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper: Gerotarget (Focus on Aging)
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5239442/
https://ncbi.nlm.nih.gov/pubmed/27472463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10854
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