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Oxetane modified, conformationally constrained, antisense oligodeoxyribonucleotides function efficiently as gene silencing molecules
Incorporation of nucleosides with novel base-constraining oxetane (OXE) modifications [oxetane, 1-(1′,3′-O-anhydro-β-d-psicofuranosyl nucleosides)] into antisense (AS) oligodeoxyribonucleotides (ODNs) should greatly improve the gene silencing efficiency of these molecules. This is because OXE modifi...
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Main Authors: | , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Oxford University Press
2004
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC528787/ https://ncbi.nlm.nih.gov/pubmed/15514112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh893 |
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