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A polymer library approach to suicide gene therapy for cancer

Optimal gene therapy for cancer must (i) deliver DNA to tumor cells with high efficiency, (ii) induce minimal toxicity, and (iii) avoid gene expression in healthy tissues. To this end, we generated a library of >500 degradable, poly(β-amino esters) for potential use as nonviral DNA vectors. Using...

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Main Authors: Anderson, Daniel G., Peng, Weidan, Akinc, Akin, Hossain, Naushad, Kohn, Anat, Padera, Robert, Langer, Robert, Sawicki, Janet A.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2004
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC528737/
https://ncbi.nlm.nih.gov/pubmed/15520369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407218101
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