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Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53
TP53 missense mutations produce a mutant p53 protein that cannot activate the p53 tumor suppressive transcriptional response, which is the primary selective pressure for TP53 mutation. Specific codons of TP53, termed hotspot mutants, are mutated at elevated frequency. Hotspot forms of mutant p53 pos...
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| Pubblicato in: | Cold Spring Harb Perspect Med |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5287061/ https://ncbi.nlm.nih.gov/pubmed/27836911 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a026054 |
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