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Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53
TP53 missense mutations produce a mutant p53 protein that cannot activate the p53 tumor suppressive transcriptional response, which is the primary selective pressure for TP53 mutation. Specific codons of TP53, termed hotspot mutants, are mutated at elevated frequency. Hotspot forms of mutant p53 pos...
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| Published in: | Cold Spring Harb Perspect Med |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Cold Spring Harbor Laboratory Press
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5287061/ https://ncbi.nlm.nih.gov/pubmed/27836911 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a026054 |
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