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Does control of mutant p53 by Mdm2 complicate cancer therapy?
Missense mutant forms of p53 are expressed at high levels in some human cancers and may contribute to oncogenesis. In this issue of Genes & Development, Terzian and colleagues (pp. 1337–1344) describe a mutant p53 knock-in mouse in which normal tissues and some tumors have low levels of mutant p...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Cold Spring Harbor Laboratory Press
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2732409/ https://ncbi.nlm.nih.gov/pubmed/18483214 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1680508 |
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