Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) harbors the worst prognosis of any common solid tumor, and multiple failed clinical trials indicate therapeutic recalcitrance. Here we use exome sequencing of patient tumors and find multiple conserved genetic alterations. However, the majority of tumors exhib...

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Bibliografiset tiedot
Julkaisussa:Cell Rep
Päätekijät: Witkiewicz, Agnieszka K., Balaji, Uthra, Eslinger, Cody, McMillan, Elizabeth, Posner, Bruce, Mills, Gordon B., O’Reilly, Eileen M., Knudsen, Erik S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5287055/
https://ncbi.nlm.nih.gov/pubmed/27498862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.07.023
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