Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) harbors the worst prognosis of any common solid tumor, and multiple failed clinical trials indicate therapeutic recalcitrance. Here we use exome sequencing of patient tumors and find multiple conserved genetic alterations. However, the majority of tumors exhib...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Witkiewicz, Agnieszka K., Balaji, Uthra, Eslinger, Cody, McMillan, Elizabeth, Posner, Bruce, Mills, Gordon B., O’Reilly, Eileen M., Knudsen, Erik S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5287055/
https://ncbi.nlm.nih.gov/pubmed/27498862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.07.023
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