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Redirecting RNA splicing by SMAD3 turns TGF-β into a tumor promoter
Transforming growth factor β (TGF-β) is a well-known growth inhibitor of normal epithelial cells, but it is also secreted by solid tumors to promote cancer progression. Our recent discovery of SMAD3-PCBP1 complex with direct RNA-binding properties has shed light on how this conversion is implemented...
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| Publicado no: | Mol Cell Oncol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5287005/ https://ncbi.nlm.nih.gov/pubmed/28197539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2016.1265699 |
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