Direct regulation of alternative splicing by SMAD3 through PCBP1 is essential to the tumor-promoting role of TGF-β

In advanced stages of cancers, TGF-β promotes tumor progression in conjunction with inputs from receptor tyrosine kinase pathways. However, mechanisms that underpin the signaling cooperation and convert TGF-β from a potent growth inhibitor to a tumor promoter are not fully understood. We report here...

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Vydáno v:Mol Cell
Hlavní autoři: Tripathi, Veenu, Sixt, Katherine M, Gao, Shaojian, Xu, Xuan, Huang, Jing, Weigert, Roberto, Zhou, Ming, Zhang, Ying E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123764/
https://ncbi.nlm.nih.gov/pubmed/27746021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.09.013
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