Inhibition of demethylase KDM6B sensitizes diffuse large B-cell lymphoma to chemotherapeutic drugs

Histone methylation and demethylation regulate B-cell development, and their deregulation correlates with tumor chemoresistance in diffuse large B-cell lymphoma, limiting cure rates. Since histone methylation status correlates with disease aggressiveness and relapse, we investigated the therapeutic...

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Udgivet i:Haematologica
Main Authors: Mathur, Rohit, Sehgal, Lalit, Havranek, Ondrej, Köhrer, Stefan, Khashab, Tamer, Jain, Neeraj, Burger, Jan A., Neelapu, Sattva S., Davis, R. Eric, Samaniego, Felipe
Format: Artigo
Sprog:Inglês
Udgivet: Ferrata Storti Foundation 2017
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286945/
https://ncbi.nlm.nih.gov/pubmed/27742770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2016.144964
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