Distinct global binding patterns of the Wilms tumor gene 1 (WT1) −KTS and +KTS isoforms in leukemic cells

The zinc finger transcription factor Wilms tumor gene 1 (WT1) acts as an oncogene in acute myeloid leukemia. A naturally occurring alternative splice event between zinc fingers three and four, removing or retaining three amino acids (±KTS), is believed to change the DNA binding affinity of WT1, alth...

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Bibliographic Details
Published in:Haematologica
Main Authors: Ullmark, Tove, Järvstråt, Linnea, Sandén, Carl, Montano, Giorgia, Jernmark-Nilsson, Helena, Lilljebjörn, Henrik, Lennartsson, Andreas, Fioretos, Thoas, Drott, Kristina, Vidovic, Karina, Nilsson, Björn, Gullberg, Urban
Format: Artigo
Language:Inglês
Published: Ferrata Storti Foundation 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286941/
https://ncbi.nlm.nih.gov/pubmed/27612989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2016.149815
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