The -KTS splice variant of WT1 is essential for ovarian determination in mice

Sex determination in mammals depends on the differentiation of the supporting lineage of the gonads into Sertoli or pre-granulosa cells that govern testis and ovary development, respectively. While the Y-linked testis-determining gene Sry has been identified, the ovarian-determining factor remains u...

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Published in:Science
Main Authors: Gregoire, Elodie P, De Cian, Marie-Cécile, Migale, Roberta, Perea-Gomez, Aitana, Schaub, Sébastien, Bellido-Carreras, Natividad, Stévant, Isabelle, Mayère, Chloé, Neirijnck, Yasmine, Loubat, Agnès, Rivaud, Paul, Sopena, Miriam Llorian, Lachambre, Simon, Linssen, Margot M., Hohenstein, Peter, Lovell-Badge, Robin, Nef, Serge, Chalmel, Frédéric, Schedl, Andreas, Chaboissier, Marie-Christine
Format: Artigo
Language:Inglês
Published: 2023
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615308/
https://ncbi.nlm.nih.gov/pubmed/37917714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.add8831
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