The C1 and C2 domains of blood coagulation factor VIII mediate its endocytosis by dendritic cells

The development of inhibitory antibodies to therapeutic factor VIII is the major complication of replacement therapy in patients with hemophilia A. The first step in the initiation of the anti-factor VIII immune response is factor VIII interaction with receptor(s) on antigen-presenting cells, follow...

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Vydáno v:Haematologica
Hlavní autoři: Gangadharan, Bagirath, Ing, Mathieu, Delignat, Sandrine, Peyron, Ivan, Teyssandier, Maud, Kaveri, Srinivas V., Lacroix-Desmazes, Sébastien
Médium: Artigo
Jazyk:Inglês
Vydáno: Ferrata Storti Foundation 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286935/
https://ncbi.nlm.nih.gov/pubmed/27758819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2016.148502
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