The C1 and C2 domains of blood coagulation factor VIII mediate its endocytosis by dendritic cells

The development of inhibitory antibodies to therapeutic factor VIII is the major complication of replacement therapy in patients with hemophilia A. The first step in the initiation of the anti-factor VIII immune response is factor VIII interaction with receptor(s) on antigen-presenting cells, follow...

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Veröffentlicht in:Haematologica
Hauptverfasser: Gangadharan, Bagirath, Ing, Mathieu, Delignat, Sandrine, Peyron, Ivan, Teyssandier, Maud, Kaveri, Srinivas V., Lacroix-Desmazes, Sébastien
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ferrata Storti Foundation 2017
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286935/
https://ncbi.nlm.nih.gov/pubmed/27758819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2016.148502
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