Removal of Mannose-Ending Glycan at Asn(2118) Abrogates FVIII Presentation by Human Monocyte-Derived Dendritic Cells

The development of an immune response against therapeutic factor VIII is the major complication in hemophilia A patients. Oligomannose carbohydrates at N239 and/or N2118 on factor VIII allow its binding to the macrophage mannose receptor expressed on human dendritic cells, thereby leading to factor...

詳細記述

保存先:
書誌詳細
出版年:Front Immunol
主要な著者: Delignat, Sandrine, Rayes, Julie, Dasgupta, Suryasarathi, Gangadharan, Bagirath, Denis, Cécile V., Christophe, Olivier D., Bayry, Jagadeesh, Kaveri, Srinivas V., Lacroix-Desmazes, Sébastien
フォーマット: Artigo
言語:Inglês
出版事項: Frontiers Media S.A. 2020
主題:
Immunology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7117063/
https://ncbi.nlm.nih.gov/pubmed/32273875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00393
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