Removal of Mannose-Ending Glycan at Asn(2118) Abrogates FVIII Presentation by Human Monocyte-Derived Dendritic Cells

The development of an immune response against therapeutic factor VIII is the major complication in hemophilia A patients. Oligomannose carbohydrates at N239 and/or N2118 on factor VIII allow its binding to the macrophage mannose receptor expressed on human dendritic cells, thereby leading to factor...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Delignat, Sandrine, Rayes, Julie, Dasgupta, Suryasarathi, Gangadharan, Bagirath, Denis, Cécile V., Christophe, Olivier D., Bayry, Jagadeesh, Kaveri, Srinivas V., Lacroix-Desmazes, Sébastien
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7117063/
https://ncbi.nlm.nih.gov/pubmed/32273875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00393
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