Biphasic rapamycin effects in lymphoma and carcinoma treatment

mTOR drives tumor growth but also supports T cell function, rendering the applications of mTOR inhibitors complex especially in T cell malignancies. Here we studied the effects of the mTOR inhibitor rapamycin in mouse EL4 T cell lymphoma. Typical pharmacologic rapamycin (1–8 mg/kg) significantly red...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Liu, Yang, Pandeswara, Srilakshmi, Dao, Vinh, Padrón, Álvaro, Drerup, Justin M., Lao, Shunhua, Liu, Aijie, Hurez, Vincent, Curiel, Tyler J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286917/
https://ncbi.nlm.nih.gov/pubmed/27737881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1140
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