Accumulation of Pol Mutations Selected by HLA-B*52:01-C*12:02 Protective Haplotype-Restricted Cytotoxic T Lymphocytes Causes Low Plasma Viral Load Due to Low Viral Fitness of Mutant Viruses

HLA-B*52:01-C*12:02, which is the most abundant haplotype in Japan, has a protective effect on disease progression in HIV-1-infected Japanese individuals, whereas HLA-B*57 and -B*27 protective alleles are very rare in Japan. A previous study on HLA-associated polymorphisms demonstrated that the numb...

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Vydáno v:J Virol
Hlavní autoři: Murakoshi, Hayato, Koyanagi, Madoka, Chikata, Takayuki, Rahman, Mohammad Arif, Kuse, Nozomi, Sakai, Keiko, Gatanaga, Hiroyuki, Oka, Shinichi, Takiguchi, Masafumi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Cellular Response to Infection
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286884/
https://ncbi.nlm.nih.gov/pubmed/27903797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02082-16
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