Amino Acid Mutations in the NS4A Region of Hepatitis C Virus Contribute to Viral Replication and Infectious Virus Production

Hepatitis C virus (HCV) strain JFH-1, which belongs to genotype 2a, replicates autonomously in cultured cells, whereas another genotype 2a strain, J6CF, does not. Previously, we found that replacement of the NS3 helicase and NS5B-to-3′X regions of J6CF with those of JFH-1 confers J6CF replication co...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Murayama, Asako, Sugiyama, Nao, Suzuki, Ryosuke, Moriyama, Masaki, Nakamura, Noriko, Mochizuki, Hidenori, Wakita, Takaji, Kato, Takanobu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Genome Replication and Regulation of Viral Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286874/
https://ncbi.nlm.nih.gov/pubmed/27928005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02124-16
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