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Thymidine Kinase-Negative Herpes Simplex Virus 1 Can Efficiently Establish Persistent Infection in Neural Tissues of Nude Mice

Herpes simplex virus 1 (HSV-1) establishes latency in neural tissues of immunocompetent mice but persists in both peripheral and neural tissues of lymphocyte-deficient mice. Thymidine kinase (TK) is believed to be essential for HSV-1 to persist in neural tissues of immunocompromised mice, because in...

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Bibliografski detalji
Izdano u:J Virol
Glavni autori: Huang, Chih-Yu, Yao, Hui-Wen, Wang, Li-Chiu, Shen, Fang-Hsiu, Hsu, Sheng-Min, Chen, Shun-Hua
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286872/
https://ncbi.nlm.nih.gov/pubmed/27974554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01979-16
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