Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation

We show that ATM kinase inhibition using AZ31 prior to 9 or 9.25 Gy total body irradiation (TBI) reduced median time to moribund in mice to 8 days. ATR kinase inhibition using AZD6738 prior to TBI did not reduce median time to moribund. The striking finding associated with ATM inhibition prior to TB...

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Udgivet i:Sci Rep
Main Authors: Vendetti, Frank P., Leibowitz, Brian J., Barnes, Jennifer, Schamus, Sandy, Kiesel, Brian F., Abberbock, Shira, Conrads, Thomas, Clump, David Andy, Cadogan, Elaine, O’Connor, Mark J., Yu, Jian, Beumer, Jan H., Bakkenist, Christopher J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286430/
https://ncbi.nlm.nih.gov/pubmed/28145510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41892
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