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Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype

Reduced oxygen availability (hypoxia) leads to increased production of reactive oxygen species (ROS) by the electron transport chain. Here, I review recent work delineating mechanisms by which hypoxia‐inducible factor 1 (HIF‐1) mediates adaptive metabolic responses to hypoxia, including increased fl...

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Bibliographic Details
Published in:EMBO J
Main Author: Semenza, Gregg L
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286373/
https://ncbi.nlm.nih.gov/pubmed/28007895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695204
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