Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids

DNA:RNA hybrids, nucleic acid structures with diverse physiological functions, can disrupt genome integrity when dysregulated. Human telomeres were shown to form hybrids with the lncRNA TERRA, yet the formation and distribution of these hybrids among telomeres, their regulation and their cellular ef...

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Publicado no:Nat Commun
Main Authors: Sagie, Shira, Toubiana, Shir, Hartono, Stella R., Katzir, Hagar, Tzur-Gilat, Aya, Havazelet, Shany, Francastel, Claire, Velasco, Guillaume, Chédin, Frédéric, Selig, Sara
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286223/
https://ncbi.nlm.nih.gov/pubmed/28117327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14015
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