Characterization and rescue of telomeric abnormalities in ICF syndrome type I fibroblasts

Mutations in the human DNA methyltransferase 3B (DNMT3B) gene lead to ICF (immunodeficiency, centromeric region instability, and facial anomalies) syndrome type I. We have previously described a telomere-related phenotype in cells from these patients, involving severe hypomethylation of subtelomeric...

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Detalhes bibliográficos
Main Authors: Yehezkel, Shiran, Shaked, Rony, Sagie, Shira, Berkovitz, Ron, Shachar-Bener, Hofit, Segev, Yardena, Selig, Sara
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584450/
https://ncbi.nlm.nih.gov/pubmed/23450006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2013.00035
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