Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling

Ischaemic heart disease limits oxygen and metabolic substrate availability to the heart, resulting in tissue death. Here, we demonstrate that the AMP-activated protein kinase (AMPK)-related protein Snf1-related kinase (SNRK) decreases cardiac metabolic substrate usage and mitochondrial uncoupling, a...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Rines, Amy K., Chang, Hsiang-Chun, Wu, Rongxue, Sato, Tatsuya, Khechaduri, Arineh, Kouzu, Hidemichi, Shapiro, Jason, Shang, Meng, Burke, Michael A., Abdelwahid, Eltyeb, Jiang, Xinghang, Chen, Chunlei, Rawlings, Tenley A., Lopaschuk, Gary D., Schumacker, Paul T., Abel, E. Dale, Ardehali, Hossein
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286102/
https://ncbi.nlm.nih.gov/pubmed/28117339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14095
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