Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling

Ischaemic heart disease limits oxygen and metabolic substrate availability to the heart, resulting in tissue death. Here, we demonstrate that the AMP-activated protein kinase (AMPK)-related protein Snf1-related kinase (SNRK) decreases cardiac metabolic substrate usage and mitochondrial uncoupling, a...

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Publicat a:Nat Commun
Autors principals: Rines, Amy K., Chang, Hsiang-Chun, Wu, Rongxue, Sato, Tatsuya, Khechaduri, Arineh, Kouzu, Hidemichi, Shapiro, Jason, Shang, Meng, Burke, Michael A., Abdelwahid, Eltyeb, Jiang, Xinghang, Chen, Chunlei, Rawlings, Tenley A., Lopaschuk, Gary D., Schumacker, Paul T., Abel, E. Dale, Ardehali, Hossein
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286102/
https://ncbi.nlm.nih.gov/pubmed/28117339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14095
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