Dynamics of BAF- Polycomb Complex Opposition on Heterochromatin in Normal and Oncogenic States

The opposition between polycomb repressive complexes (PRC) and BAF (mSWI/SNF) complexes plays critical roles in development and disease. Mutations in the genes encoding BAF subunits contribute to over 20% of human malignancy, yet the underlying mechanisms remain unclear owing largely to a lack of as...

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Udgivet i:Nat Genet
Main Authors: Kadoch, Cigall, Williams, Robert T., Calarco, Joseph P., Miller, Erik L., Weber, Christopher M., Braun, Simon G., Pulice, John L., Chory, Emma J., Crabtree, Gerald R.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5285326/
https://ncbi.nlm.nih.gov/pubmed/27941796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3734
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