The cyclin-dependent kinase inhibitor AT7519 accelerates neutrophil apoptosis in sepsis-related acute respiratory distress syndrome

Acute respiratory distress syndrome (ARDS) is a neutrophil-dominant disorder with no effective pharmacological therapies. While the cyclin-dependent kinase inhibitor AT7519 induces neutrophil apoptosis to promote inflammation resolution in preclinical models of lung inflammation, its potential effic...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Thorax
Hauptverfasser: Dorward, David A, Felton, Jennifer M, Robb, Calum T, Craven, Thomas, Kipari, Tiina, Walsh, Timothy S, Haslett, Christopher, Kefala, Kallirroi, Rossi, Adriano G, Lucas, Christopher D
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2017
Schlagworte:
Research Letter
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5284332/
https://ncbi.nlm.nih.gov/pubmed/27965411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2016-209229
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