The cyclin-dependent kinase inhibitor AT7519 accelerates neutrophil apoptosis in sepsis-related acute respiratory distress syndrome

Acute respiratory distress syndrome (ARDS) is a neutrophil-dominant disorder with no effective pharmacological therapies. While the cyclin-dependent kinase inhibitor AT7519 induces neutrophil apoptosis to promote inflammation resolution in preclinical models of lung inflammation, its potential effic...

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Detalhes bibliográficos
Publicado no:Thorax
Main Authors: Dorward, David A, Felton, Jennifer M, Robb, Calum T, Craven, Thomas, Kipari, Tiina, Walsh, Timothy S, Haslett, Christopher, Kefala, Kallirroi, Rossi, Adriano G, Lucas, Christopher D
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2017
Assuntos:
Research Letter
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5284332/
https://ncbi.nlm.nih.gov/pubmed/27965411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2016-209229
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