Transforming growth factor-β plays divergent roles in modulating vascular remodeling, inflammation, and pulmonary fibrosis in a murine model of scleroderma

The efficacy and feasibility of targeting transforming growth factor-β (TGFβ) in pulmonary fibrosis and lung vascular remodeling in systemic sclerosis (SSc) have not been well elucidated. In this study we analyzed how blocking TGFβ signaling affects pulmonary abnormalities in Fos-related antigen 2 (...

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Bibliographic Details
Published in:Am J Physiol Lung Cell Mol Physiol
Main Authors: Tsujino, Kazuyuki, Reed, Nilgun Isik, Atakilit, Amha, Ren, Xin, Sheppard, Dean
Format: Artigo
Language:Inglês
Published: American Physiological Society 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283926/
https://ncbi.nlm.nih.gov/pubmed/27864286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00428.2016
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