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Kupffer cells facilitate the acute effects of leptin on hepatic lipid metabolism

Leptin has potent effects on lipid metabolism in a number of peripheral tissues. In liver, an acute leptin infusion (~120 min) stimulates hepatic fatty acid oxidation (~30%) and reduces triglycerides (TG, ~40%), effects that are dependent on phosphoinositol-3-kinase (PI3K) activity. In the current s...

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Detalhes bibliográficos
Publicado no:Am J Physiol Endocrinol Metab
Main Authors: Metlakunta, Anantha, Huang, Wan, Stefanovic-Racic, Maja, Dedousis, Nikolaos, Sipula, Ian, O’Doherty, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283880/
https://ncbi.nlm.nih.gov/pubmed/27827807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00250.2016
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