PET of Poly (ADP-Ribose) Polymerase Activity in Cancer: Preclinical Assessment and First In-Human Studies

PURPOSE: To demonstrate that positron emission tomography (PET) with fluorine 18 ((18)F) fluorthanatrace (FTT) depicts activated poly (adenosine diphosphate–ribose)polymerase (PARP) expression and is feasible for clinical trial evaluation. MATERIALS AND METHODS: All studies were conducted prospectiv...

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Detalhes bibliográficos
Publicado no:Radiology
Main Authors: Michel, Loren S., Dyroff, Samantha, Brooks, Frank J., Spayd, Katherine J., Lim, Sora, Engle, Jacquelyn T., Phillips, Sharon, Tan, Benjamin, Wang-Gillam, Andrea, Bognar, Christopher, Chu, Wenhua, Zhou, Dong, Mach, Robert H., Laforest, Richard, Chen, Delphine L.
Formato: Artigo
Idioma:Inglês
Publicado em: Radiological Society of North America 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283874/
https://ncbi.nlm.nih.gov/pubmed/27841728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1148/radiol.2016161929
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