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Relationship between mutant SOD1 maturation and inclusion formation in cell models

A common property of Cu/Zn superoxide dismutase 1 (SOD1), harboring mutations associated with amyotrophic lateral sclerosis (ALS), is a high propensity to misfold and form abnormal aggregates. The aggregation of mutant SOD1 has been demonstrated in vitro, with purified proteins, in mouse models, in...

詳細記述

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書誌詳細
出版年:J Neurochem
主要な著者: Ayers, Jacob I., McMahon, Benjamin, Gill, Sabrina, Lelie, Herman L., Fromholt, Susan, Brown, Hilda, Valentine, Joan Selverstone, Whitelegge, Julian P., Borchelt, David R.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283795/
https://ncbi.nlm.nih.gov/pubmed/27727458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13864
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