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Master Regulators of Oncogenic KRAS Response in Pancreatic Cancer: An Integrative Network Biology Analysis

BACKGROUND: KRAS is the most frequently mutated gene in pancreatic ductal adenocarcinoma (PDAC), but the mechanisms underlying the transcriptional response to oncogenic KRAS are still not fully understood. We aimed to uncover transcription factors that regulate the transcriptional response of oncoge...

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Veröffentlicht in:PLoS Med
Hauptverfasser: Sivakumar, Shivan, de Santiago, Ines, Chlon, Leon, Markowetz, Florian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283690/
https://ncbi.nlm.nih.gov/pubmed/28141826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1002223
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