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Master Regulators of Oncogenic KRAS Response in Pancreatic Cancer: An Integrative Network Biology Analysis

BACKGROUND: KRAS is the most frequently mutated gene in pancreatic ductal adenocarcinoma (PDAC), but the mechanisms underlying the transcriptional response to oncogenic KRAS are still not fully understood. We aimed to uncover transcription factors that regulate the transcriptional response of oncoge...

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Bibliografiset tiedot
Julkaisussa:PLoS Med
Päätekijät: Sivakumar, Shivan, de Santiago, Ines, Chlon, Leon, Markowetz, Florian
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283690/
https://ncbi.nlm.nih.gov/pubmed/28141826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1002223
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