Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis

Oncogenic KRAS is the key driver of pancreatic ductal adenocarcinoma (PDAC). We previously described a role for KRAS in PDAC tumor maintenance through rewiring of cellular metabolism to support proliferation. Understanding the details of this metabolic reprogramming in human PDAC may provide novel t...

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Udgivet i:Nat Commun
Main Authors: Santana-Codina, Naiara, Roeth, Anjali A., Zhang, Yi, Yang, Annan, Mashadova, Oksana, Asara, John M., Wang, Xiaoxu, Bronson, Roderick T., Lyssiotis, Costas A., Ying, Haoqiang, Kimmelman, Alec C.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6251888/
https://ncbi.nlm.nih.gov/pubmed/30470748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07472-8
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