Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis

Oncogenic KRAS is the key driver of pancreatic ductal adenocarcinoma (PDAC). We previously described a role for KRAS in PDAC tumor maintenance through rewiring of cellular metabolism to support proliferation. Understanding the details of this metabolic reprogramming in human PDAC may provide novel t...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Foilsithe in:Nat Commun
Main Authors: Santana-Codina, Naiara, Roeth, Anjali A., Zhang, Yi, Yang, Annan, Mashadova, Oksana, Asara, John M., Wang, Xiaoxu, Bronson, Roderick T., Lyssiotis, Costas A., Ying, Haoqiang, Kimmelman, Alec C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2018
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6251888/
https://ncbi.nlm.nih.gov/pubmed/30470748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07472-8
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla