Targeting Ewing sarcoma with activated and GD2-specific chimeric antigen receptor-engineered human NK cells induces upregulation of immune-inhibitory HLA-G

Activated and in vitro expanded natural killer (NK) cells have substantial cytotoxicity against many tumor cells, but their in vivo efficacy to eliminate solid cancers is limited. Here, we used chimeric antigen receptors (CARs) to enhance the activity of NK cells against Ewing sarcomas (EwS) in a tu...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncoimmunology
Prif Awduron: Kailayangiri, Sareetha, Altvater, Bianca, Spurny, Christian, Jamitzky, Silke, Schelhaas, Sonja, Jacobs, Andreas H., Wiek, Constanze, Roellecke, Katharina, Hanenberg, Helmut, Hartmann, Wolfgang, Wiendl, Heinz, Pankratz, Susann, Meltzer, Jutta, Farwick, Nicole, Greune, Lea, Fluegge, Maike, Rossig, Claudia
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2016
Pynciau:
MIATA Compliant Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283645/
https://ncbi.nlm.nih.gov/pubmed/28197367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1250050
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