Targeting Ewing sarcoma with activated and GD2-specific chimeric antigen receptor-engineered human NK cells induces upregulation of immune-inhibitory HLA-G

Activated and in vitro expanded natural killer (NK) cells have substantial cytotoxicity against many tumor cells, but their in vivo efficacy to eliminate solid cancers is limited. Here, we used chimeric antigen receptors (CARs) to enhance the activity of NK cells against Ewing sarcomas (EwS) in a tu...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Kailayangiri, Sareetha, Altvater, Bianca, Spurny, Christian, Jamitzky, Silke, Schelhaas, Sonja, Jacobs, Andreas H., Wiek, Constanze, Roellecke, Katharina, Hanenberg, Helmut, Hartmann, Wolfgang, Wiendl, Heinz, Pankratz, Susann, Meltzer, Jutta, Farwick, Nicole, Greune, Lea, Fluegge, Maike, Rossig, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
MIATA Compliant Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283645/
https://ncbi.nlm.nih.gov/pubmed/28197367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1250050
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