NKp30 isoforms and NKp30 ligands are predictive biomarkers of response to imatinib mesylate in metastatic GIST patients

Despite effective targeted therapy acting on KIT and PDGFRA tyrosine kinases, gastrointestinal stromal tumors (GIST) escape treatment by acquiring mutations conveying resistance to imatinib mesylate (IM). Following the identification of NKp30-based immunosurveillance of GIST and the off-target effec...

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Publicado no:Oncoimmunology
Main Authors: Rusakiewicz, Sylvie, Perier, Aurélie, Semeraro, Michaela, Pitt, Jonathan M., Pogge von Strandmann, Elke, Reiners, Katrin S., Aspeslagh, Sandrine, Pipéroglou, Christelle, Vély, Frédéric, Ivagnes, Alexandre, Jegou, Sarah, Halama, Niels, Chaigneau, Loic, Validire, Pierre, Christidis, Christos, Perniceni, Thierry, Landi, Bruno, Berger, Anne, Isambert, Nicolas, Domont, Julien, Bonvalot, Sylvie, Terrier, Philippe, Adam, Julien, Coindre, Jean-Michel, Emile, Jean-François, Poirier-Colame, Vichnou, Chaba, Kariman, Rocha, Benedita, Caignard, Anne, Toubert, Antoine, Enot, David, Koch, Joachim, Marabelle, Aurélien, Lambert, Marion, Caillat-Zucman, Sophie, Leyvraz, Serge, Auclair, Christian, Vivier, Eric, Eggermont, Alexander, Borg, Christophe, Blay, Jean-Yves, Le Cesne, Axel, Mir, Olivier, Zitvogel, Laurence
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283614/
https://ncbi.nlm.nih.gov/pubmed/28197361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1137418
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